Quick Index
 Adult Industry News
Search AINews Database
Type Keyword or Phrase Here
Advertise with AINews Pornography feminists unshackle their desires and celebrate their sexuality in the patriarchal world

Front Page
Film News
Media News
Business News
Clubs & Appearances
Law & Politics
Internet & Mobile News
Lifestyles Arts Health Charity
Letters to the Editor
Movie Spotlight Reviews
Pornstar Pages
AINews Staff
Ad Rates
PR 101: Press Release Service

Porn for GEEKS! Meet me & my friends!

Join Tera Patrick

December 06, 2002 05:33pm
Viagra Linked to Rough Sex
Source: Reuters
by: Todd Zwillich

(WASHINGTON, DC) -- A debate has begun among scientists about whether Pfizer Inc.'s impotence drug Viagra (sildenafil) can be linked to aggressive behavior and sexual violence.

One researcher has concluded that doctors should begin warning Viagra users about the possibility of psychological and emotional side effects.

But other scientists, as well as officials at Pfizer, reject the claim as unsound.

In July of this year, Dr. Harold a. Milman, a toxicologist based in Rockville, Maryland, published a report in the Annals of Pharmacotherapy examining more than 12,000 reports of adverse events in men who took Viagra.

More than 270 of the reports, collected and archived by the US Food and Drug Administration (FDA), detailed psychological side effects, including dizziness, disorientation and amnesia. The drug was also listed as a suspect in 22 reports involving aggression, 13 involving rape and 6 involving murder, according to Milman's article.

FDA officials said that they have no plans to change Viagra's labeling in light of Milman's report. But one top agency official said that the study was important to scientific debate about the drug.

"(The report) had a lot of information that hadn't been pulled together in one place before," Dr. Bernard Schwetz, FDA's senior advisor for science, said in an interview.

Milman acknowledged that the adverse-event reports are anecdotal evidence. "But it's clear that these men are behaving abnormally," he told Reuters Health.

The theory that the drug may cause aggression has formed the basis of the so-called "Viagra defense," a claim made by half a dozen defendants since 1998 that the drug caused them to commit violent crimes. Milman was hired as an expert witness in one such case.

The Viagra defense has not been successful so far, but an Israeli court did mention in a 1999 ruling against a rapist that the drug had played a role in the attack.

Viagra causes erections by working directly on the blood vessels of the penis, not through actions in the brain. Clinical studies in more than 8,000 men showed that the drug caused central nervous system effects in less than 2% of users, none of whom became violent or disoriented, according to Pfizer.

"I'm not saying Viagra causes anything, but there is evidence to suggest an association," said Milman, who noted that he is not an expert in Viagra's biological mechanisms. Milman spent 18 years as a senior advisor at the US Environmental Protection Agency and 10 as a cancer-drug expert at the National Institutes of Health.

Scientists don't consider adverse-event reports to be hard evidence of a causal link between a drug and an event. The reports don't always show which other drugs patients were taking or note their state of health when taking the medication.

"You could take any product and connect individuals who use it with certain behaviors. I think it's a coincidence," said Geoff Cook, a Pfizer spokesman. "We don't think there is any credible medical evidence linking Viagra with violent or aggressive behavior."

Still, adverse-event reports are often used as a way to flag side effects in the general population that may have been missed during clinical studies. Effects that fail to show up in several thousand test subjects have a better chance of being noticed when millions of people have taken a drug.

Milman cited research in his report showing that sildenafil can enter the brain and that the drug could affect biological pathways in parts of the brain controlling sexual responses and aggression.

In interviews, other scientists rejected Milman's claims about a link to aggressive behavior. "To me, it is an extremely remote hypothesis," said Dr. Raymond C. Rosen, a professor of psychiatry and medicine at the University of Medicine and Dentistry of New Jersey.

Rosen and Northwestern University toxicologist Dr. Kevin E. McKenna wrote to the Annals of Pharmacotherapy this month challenging Milman's article.

Rosen told Reuters Health that there is no clinical evidence in humans that the biological pathways affected by Viagra can cause aggression or violence. He said that no patient he has ever evaluated has shown such symptoms.

"Changing anything clinically or legally because of this is stretching the point totally beyond credibility," said Rosen, who is recognized as a leading expert in sexual dysfunction. He noted that he has served in the past as a paid consultant for Pfizer.

McKenna acknowledged that sildenafil could affect parts of the brain that control sexual behavior, including the hypothalamus and parts of the medulla. But studies in mice show that the drug would probably make aggression less likely, not more likely, he said.

Milman said his paper was intended to encourage more scientists to look directly at whether Viagra can cause problems. "There are a lot of question marks," he said.

On that point, McKenna agreed. "I still believe behavioral effects of sildenafil should be studied more closely," he said.

Advertise with AINews

Related Stories

Related Sites - WARNING! Graphic Content



Top Stories

Scott Taylor Interview

MWA: 01/16/18

Happy New Year 2018

MWA: 12/26/17

MWA: 12/21/17

2018 AVN Awards Nominees

MWA: 12/16/17

MWA: 12/10/17

MWA: 12/09/17

A Season for Hope

MWA: 12/06/17

MWA: 12/05/17

Gonzo with Eddie Powell

Guild Demands New HIV Testing!

ED Award Winners

MWA: 11/07/17

Burlesque Documentary

Farrah Abraham Fired for Porn Return

Heaven and Hell 2017

Stories From

Lifestyles Arts Health Charity

Happy New Year 2018

A Season for Hope

Guild Demands New HIV Testing!

Help Heal Rhiannon

Bill Margold Memorial Fund

Take Care and Care Take

Bill Margold Memorial (UPDATED)

Bill Margold Died

TTS Discount at LV Office

Goodbye 2016, Hello 2017!

Happy Xanukkah, Merry XXXmas

Rodney Moore Covers Glen Campbell Song

DomCon New Orleans

APAG Support Group

Elizabeth Starr May Lose Breasts

Sheri's Ranch Joint Venture

CineKink Oakland 9/8

Skirt Club Party

Sex Workers Anthem

Fetish Con Party Schedule

Nadia Ali Interview

Freedom Acres Party

Porn Star by Herschel Savage

CatalystCon Sessions, Speakers

Naughty Massage

Ocean News from Lexi Love

Happy New Year 2016!

See Jack Napier

Merry XXXmas, Happy Xanukkah

Calvert Joins Gamelink

Richelle Ryan Naked Yoga

Sheri's Ranch Views Prostitutes

Candida Royalle Passes

Cleopatra Dead

Danger Builds Darth Vibrader

Vice is Nice Event

D Wise Fights for Life

Freedom Acres Anniversary Party

Girlfriends Celebrates Caitlyn Jenner

Welcome 2015!

Actress as an Artist

Merry XXXmas, Happy Xanukkah

Pushed Into the Corner

Bright Lights, Lonely Nights

Halloween Art Show

Sex Workshop Hustler San Diego

Fake Test Results

CET Free Panel Month

TTS Welcomes Bobi & Jen

Cutting Edge Changes Staff

Next Day Test in LV

Copyright © 1998 - 2018 Adult Industry News (AINews.com)
All materials constituting text, articles, press releases, stories, columns, photographs, graphics, and code on the AINews.com domain are protected by copyright, and either owned by Adult Industry News (AINews.com), or reproduced with permission from other copyright owners. It may be downloaded and printed for personal reference, but not otherwise copied, altered in any way, or transmitted to others, without the written permission of Adult Industry News (AINews.com).